Pubblicazione scientifica

Evaluation of the Cardiotoxicity of Evodiamine In Vitro and In Vivo

FILONE TECNOLOGICO	TEMA
produzione e raccolta

RIASSUNTO

Evodiamine is a bioactive alkaloid that is specified as a biomarker for the quality assessment of Evodia rutaecarpa (E. rutaecarpa) and for traditional Chinese medicines containing this plant. We previously reported that quantitative structure–activity modeling indicated that evodiamine may cause cardiotoxicity. However, previous investigations have indicated that evodiamine has beneficial effects in patients with cardiovascular diseases and there are no previous in vitro or in vivo reports of evodiamine-induced cardiotoxicity. The present study investigated the effects of evodiamine on primary cultured neonatal rat cardiomyocytes in vitro, and on zebrafish in vivo. Cell viability was reduced in vitro, where evodiamine had a 24 h 50% inhibitory concentration of 28.44 µg/mL. Cells exposed to evodiamine also showed increased lactate dehydrogenase release and maleic dialdehyde levels, and reduced superoxide dismutase activity. In vivo, evodiamine had a 10% lethal concentration of 354 ng/mL and induced cardiac malfunction, as evidenced by changes in heart rate and circulation, and pericardial malformations. This study indicated that evodiamine could cause cardiovascular side effects involving oxidative stress. These findings suggest that cardiac function should be monitored in patients receiving preparations containing evodiamine.

DATA

Data di pubblicazione: 09/06/2017

AUTORI

YANG WEIFENG
MA LINA
LI SIDI
CUI KAIYU
LEI LEI
YE ZUGUANG

ENTE DI AFFERENZA

EXPERIMENTAL RSCH CTR CHINA ACAD CHINESE MEDICAL SCIENCES BEIJING 100700 CHINA SUNZHUYANG 126 COM
INST CHINESE MATERIA MEDICA CHINA ACAD CHINESE MEDICAL SCIENCES BEIJING 100700 CHINA MALINA8512 163 COM LM LISIDIMAA ALIYUN COM SL
PHARMACY FACULTY HUBEI UNIV CHINESE MEDICINE WUHAN 430065 CHINA CKY1555 SINA COM
INST INFO ON TCM CHINA ACAD CHINESE MEDICAL SCIENCES BEIJING 100700 CHINA SOPHLEI HOTMAIL COM

RIVISTA

Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry, 22(6), 943

IMPACT FACTOR

3,010

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