Pubblicazione scientifica

Lifelong neurogenesis in the cerebral ganglion of the Chinese mud snail, Cipangopaludina chinensis

FILONE TECNOLOGICO	TEMA
produzione e raccolta

RIASSUNTO

Abstract

Introduction

A small group of Gastropods possessing giant neurons have long been used to study a wide variety of fundamental neurophysiological phenomena. However, the majority of gastropods do not have large neurons but instead have large numbers of small neurons and remain largely unstudied. We explored neuron size and rate of increase in neuron numbers in the Chinese mud snail, Cipangopaludina chinensis.

Methods

Using histological sections and whole mounts of the cerebral ganglia, we collected cross‐sectional data on neuron number and size across the lifespan of this animal. Neurogenesis was verified using Click‐it EdU staining.

Results

We found that total neuron number in the cerebral ganglia increases throughout the lifespan of this species at a constant rate. New neurons arise primarily near the nerve roots. Females live longer (up to 7 years) than males (up to 5 years) and thus achieve larger numbers of neurons in the cerebral ganglion. Neuron size is consistently small (<10 μm) in the cerebral ganglia at all ages, however, cells in the posterior section of the cerebral ganglia are modestly but significantly larger than cells at the anterior.

Conclusions

These features suggest that C. chinensis and similar species of Caenogastropoda are good candidates for studying gastropod neurogenesis, senescence, and sex differences in the nervous system.

DATA

Data di pubblicazione: 03/03/2017

AUTORI

SWART CHARLES C
WATTENBERGER AMELIA
HACKETT AMY
ISAMAN DANIELLE

ENTE DI AFFERENZA

NEUROSCIENCE PROGRAM TRINITY COLLEGE HARTFORD CT USA
TRINITY COLLEGE HARTFORD CT USA

RIVISTA

Brain and Behavior, 7(4), e00652

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