Pubblicazione scientifica

A Possible Role of Intestinal Microbiota in the Pathogenesis of Ankylosing Spondylitis

FILONE TECNOLOGICO	TEMA
produzione e raccolta

RIASSUNTO

Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the sacroiliac joints and the spine, for which the pathogenesis is thought to be a result of the combination of host genetic factors and environmental triggers. However, the precise factors that determine one’s susceptibility to AS remain to be unraveled. With 100 trillion bacteria residing in the mammalian gut having established a symbiotic relation with their host influencing many aspects of host metabolism, physiology, and immunity, a growing body of evidence suggests that intestinal microbiota may play an important role in AS. Several mechanisms have been suggested to explain the potential role of the microbiome in the etiology of AS, such as alterations of intestinal permeability, stimulation of immune responses, and molecular mimicry. In this review, the existing evidence for the involvement of the microbiome in AS pathogenesis was discussed and the potential of intestinal microbiome-targeting strategies in the prevention and treatment of AS was evaluated.

DATA

Data di pubblicazione: 17/12/2016

AUTORI

YANG LIANJUN
WANG LIPING
WANG XIN
XIAN CORY J
LU HAI

ENTE DI AFFERENZA

ACAD ORTHOPEDICS OF GUANGDONG PROVINCE ORTHOPAEDIC HOSPITAL OF GUANGDONG PROVINCE DEPT ORTHOPEDIC SURGERY THIRD AFFILIATED HOSPITAL OF SOUTHERN MEDICAL UNIV GUANGZHOU 510630 CHINA LIANJUNYANG1988 163 COM LY LIPING WANG MYMAIL UNISA EDU AU LW
SANSOM INST HEALTH RSCH & SCHOOL OF PHARMACY & MEDICAL SCIENCES UNIV SOUTH AUSTRALIA ADELAIDE SA5001 AUSTRALIA
INST HEALTH & BIOMEDICAL INNOV QUEENSLAND UNIV TECH BRISBANE QLD4059 AUSTRALIA X56 WANG HDR QUT EDU AU

RIVISTA

International Journal of Molecular Sciences, 17(12), 2126

IMPACT FACTOR

4,210

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